Although it has been determined that every individual will inevitably experience some degree of degenerative knee joint disease, there are certain risk factors that may make individuals more susceptible.

Age
The prevalence of osteoarthritis has been shown to increase significantly with age.

Gender
Up to age 45, osteoarthritis is more common in men; after age 45, the disease is more common in women.

Heredity
Genetics and family history make some individuals more susceptible to developing osteoarthritis. These traits include joint laxity, abnormalities that prevent joints from fitting together properly, or a defect in the gene that produces collagen, the protein found in cartilage.

Obesity
Obesity is the greatest risk factor for developing OA of the knee. Weight loss and lifestyle modification are often the first treatment options.

Previous Injury or Overuse
Repeated injury or previous trauma to the knee joint increases the risk of developing osteoarthritis. Athletes who have repeatedly sustained injuries to their knees have an increased risk of developing osteoarthritis.